Efficacy of remimazolam combined with low-dose propofol for sedation during induction of anesthesia
10.3760/cma.j.cn131073.20210518.00712
- VernacularTitle:瑞马唑仑复合小剂量丙泊酚用于麻醉诱导时镇静的效果
- Author:
Rong ZHANG
1
;
Zeyu ZHAO
;
Xinxue WANG
;
Yong TAO
;
Wenjun ZOU
;
Qian WANG
;
Xiang LI
;
Chaoyang CHEN
;
Xinxin YUE
Author Information
1. 成都中医药大学附属四川省康复医院麻醉科 611135
- Keywords:
Benzodiazepines;
Propofol;
Anesthesia, general;
Deep sedation
- From:
Chinese Journal of Anesthesiology
2021;41(7):820-822
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy of remimazolam combined with low-dose propofol for sedation during induction of anesthesia.Methods:A total of 228 patients of both sexes, aged 18-64 yr, with body mass index of 19-35 kg/m 2, of American Society of Anesthesiologists physical status Ⅰ-Ⅲ, undergoing elective laparoscopic cholecystectomy, were divided into 2 groups ( n=114 each) by a random number table method: remimazolam combined with low-dose propofol group (group R) and propofol group (group P). Anesthesia was induced with intravenous injection of sufentanil 0.3 μg/kg, remimazolam 0.3 mg/kg, propofol 0.5 mg/kg and micuronium 0.2 mg/kg in group R, and sufentanil 0.3 μg/kg, propofol 2 mg/kg and micuronium 0.2 mg/kg in group P. Endotracheal intubation was performed when bispectral index value ≤ 50.Before induction (T 0), immediately before intubation (T 1), at 1 min (T 2) and 3 min (T 3) after intubation, mean arterial pressure (MAP) and heart rate (HR) were recorded.The anesthesia induction time and the incidence of hypotension and bradycardia were recorded in the two groups. Results:There was no significant difference in MAP and HR at T 0 between the two groups ( P>0.05). Compared with the value at T 0, MAP in two groups and HR were significantly decreased at T 1-3 in group P ( P<0.01). Compared with group P, the anesthesia induction time was significantly prolonged, and hypotension and bradycardia was decreased in group R ( P<0.05). Conclusion:The combination of remimazolam and low-dose propofol exerts better efficacy for sedation during induction of anesthesia than propofol alone.
