Relationship between degrees of biliary obstruction and levels of lipid peroxidation in patients
10.3760/cma.j.cn131073.20200812.00607
- VernacularTitle:患者胆道梗阻程度与脂质过氧化水平的关系
- Author:
Moran WANG
1
;
Jian HUANG
;
Yongshuai LI
;
Jianteng GU
;
Bin YI
;
Kaizhi LU
;
Jiaolin NING
Author Information
1. 陆军军医大学第一附属医院麻醉科，重庆 400038
- Keywords:
Bile duct neoplasms;
Lipid peroxidation
- From:
Chinese Journal of Anesthesiology
2021;41(6):667-669
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the relationship between degrees of biliary obstruction and levels of lipid peroxidation in patients.Methods:A total of 140 patients of both sexes, with biliary obstruction, without biliary puncture and drainage, aged 40-64 yr, with body mass index of 18.5-23.9 kg/m 2, of American Society of Anesthesiologists physical status Ⅱ or Ⅲ, were selected.The patients with different degrees of biliary obstruction were divided into 4 groups ( n=35 each) according to Child-Pugh grade total bilirubin (TBIL) concentrations: group A (TBIL<17 μmol/L), group B (17 μmol/L≤TBIL<34 μmol/L), group C (34 μmol/L≤TBIL<51 μmol/L) and group D (TBIL≥51 μmol/L). The serum TBIL, direct bilirubin (DBIL), indirect bilirubin (IBIL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bile acid (TBA) and malondialdehyde (MDA) concentrations were measured.The correlation between serum MDA concentration and degree of biliary obstruction was tested by Spearman correlation analysis. Results:Compared with group A and group B, the serum DBIL, IBIL, ALT, AST, TBA and MDA concentrations were significantly increased in group C and group D ( P<0.05), and there was no significant difference in the parameters mentioned above between group A and group B ( P>0.05). Compared with group C, the serum DBIL, IBIL, ALT, AST, TBA and MDA concentrations were significantly increased in group D ( P<0.05). Serum MDA concentration was positively correlated with degree of biliary obstruction ( r=0.54, P<0.05). Conclusion:The degree of biliary obstruction can reflect the level of lipid peroxidation in patients.
