Efficacy of different drugs in alleviating remifentanil-induced hyperalgesia: a network meta-analysis
10.3760/cma.j.cn131073.20210103.00411
- VernacularTitle:不同药物缓解瑞芬太尼致痛觉过敏的效果：网状meta分析
- Author:
Xiaoyong WEI
1
;
Linglan XU
;
Xi LIU
;
Xiaoyuan GENG
;
Wenting MA
;
Lihua JIANG
Author Information
1. 郑州大学第三附属医院麻醉科 450052
- Keywords:
Piperidines;
Hyperalgesia;
Network meta-analysis
- From:
Chinese Journal of Anesthesiology
2021;41(4):434-439
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically compare the efficacy of different drugs in alleviating remifentanil-induced hyperalgesia.Methods:Databases such as PubMed, Cochrane Library, EMBASE, Web of Science, CNKI, Wanfang Data and CBM were searched using computers from inception to May 2020.The randomized controlled trials comparing the efficacy of different intervention measures for alleviating remifentanil-induced hyperalgesia were searched.After independently identifying the literature, the two reviewers conducted data extraction and evaluated the bias of the included studies, and Stata 14.0, ADDIS 1.16.5 and R4.0.2 softwares were used to analyze the data.Results:Thirty randomized controlled trials were included in our study.Compared with placebo, 3 out of 6 drugs could alleviate remifentanil-induced hyperalgesia, and the probability order for the effect was as follows: butorphanol with MD value (95% CI)-1.50 (-2.80, -0.24), dexmedetomidine with MD value (95% CI)-1.20 (-2.40, -0.09) and ketamine with MD value (95% CI) -0.88 (-1.60, -0.16). After sensitivity analysis, the efficacy of butorphanol remained to be verified.Two drugs could decrease the dosage of opioids within 24 h after operation, and the probability order for the effect was as follows: dexmedetomidine with MD value (95% CI) -14.00 (-28.00, -0.19) and ketamine with MD value (95% CI) -9.20 (-18.00, -0.08). One drug could decrease the incidence of postoperative nausea and vomiting within 24 h after operation: dexmedetomidine with RR value (95%CI) 0.28 (0.16, 0.22). Conclusion:The results of network meta-analyses show that dexmedetomidine has the best efficacy in alleviating remifentanil-induced hyperalgesia.
