Risk factors for postoperative acute kidney injury in patients undergoing radical resection of malignant colorectal cancer
10.3760/cma.j.cn131073.20210228.00410
- VernacularTitle:结直肠恶性肿瘤根治术后急性肾损伤的危险因素
- Author:
Yining XIE
1
;
Ling YU
;
Hongyu TAN
Author Information
1. 北京大学肿瘤医院麻醉科 100142
- Keywords:
Acute kidney injury;
Postoperative complications;
Colorectal neoplasms;
Risk factors
- From:
Chinese Journal of Anesthesiology
2021;41(4):430-433
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To identify the risk factors for postoperative acute kidney injury (AKI) in patients undergoing radical resection of malignant colorectal cancer.Methods:Patients undergoing radical resection of malignant colorectal cancer from November 1, 2019 to December 1, 2020, were selected, and the medical records including gender, age, height, weight, American Society of Anesthesiologists (ASA) physical status, complications (hypertension, diabetes mellitus, coronary heart disease, chronic kidney disease and renal insufficiency), neoadjuvant therapy before surgery, preoperative serum creatinine level (within 1-3 days before surgery), preoperative prophylactic ureteral intubation, operation methods, intraoperative blood loss and blood transfusion, intraoperative fluid infusion and urine output, intraoperative hypotension occurrence and duration, intraoperative prophylactic ileostomy, operation time, postoperative length of stay, postoperative complications (ileus, anastomotic leak/abdominal infection), postoperative antibiotics and nonsteroidal anti-inflammatory drugs use were retrospectively collected.Postoperative AKI was diagnosed based on Kidney Disease Improving Global Outcomes criteria.The patients were divided into AKI group and non-AKI group according to whether postoperative AKI occurred within 7 days after surgery, and the risk factors for postoperative AKI were screened by multivariate Poisson regression analysis.Results:A total of 543 patients were included in this study.There were 14 cases of postoperative AKI and the incidence was 2.6%.Poisson regression analysis showed that preoperative hypertension ( OR=5.04, 95% confidence interval 1.57-22.18, P=0.041) and postoperative use of vancomycin ( OR=8.87, 95% confidence interval 2.27-28.99, P=0.004) were the independent risk factors for postoperative AKI. Conclusion:Preoperative hypertension and postoperative use of vancomycin are the independent risk factors for postoperative AKI in patients undergoing radical resection of malignant colorectal cancer.
