Risk factors for Gleason score changes between biopsy pathology and radical prostatectomy specimen
10.3760/cma.j.cn112330-20200309-00172
- VernacularTitle:前列腺癌穿刺活检标本与根治手术标本Gleason评分差异的影响因素
- Author:
Xiaochuan WANG
1
;
Yu ZHANG
;
Zhengguo JI
;
Peiqian YANG
;
Ye TIAN
Author Information
1. 首都医科大学附属北京友谊医院泌尿外科，北京 100050
- Keywords:
Prostatic neoplasms;
Biopsy, Needle;
Prostatectomy;
Gleason score
- From:
Chinese Journal of Urology
2021;42(12):954-957
- CountryChina
- Language:Chinese
-
Abstract:
Gleason grading system is a critical factor for assessing the risk, making treatment decision and evaluating prognosis for patients with prostate cancer. However, it has been reported that concordance rates of Gleason score between biopsy pathology and radical prostatectomy specimen were only39%-63%, whilst postsurgical upgrade and downgrade rates were 30%-55% and 7%-20% respectively. This situation brings difficulties in performing clinical practice. This literature aimed to review relevant and updated studies in literature to summarize the concordance rate and independent predictive factors of Gleason score change from following several aspects: patient clinical characteristics, biopsy-related factors, accuracy of pathologic assignment and interpretation of pathology reports. This review also investigated how the factors influenced the Gleason score change and clinical decision-making. There were many factors influencing the Gleason score change which were roughly consistent with risk factors of prostate cancer, however, some factors were controversial. In order to provide precise evaluation of risk stratification and optimal individualized treatment, it is essential to consider the risk factors which are correlated with Gleason score change.
