Research progress on MiT family translocation related renal cell carcinoma

VernacularTitle:MiT家族易位相关性肾细胞癌的研究进展
Author: Yashan WU ¹ ; Liwen RUAN ; Qiaoxin LI
Author Information

1. 新疆医科大学第一附属医院病理科，乌鲁木齐　830000
Keywords: Carcinoma, Renal cell; Translocation; Gene fusion; Gene amplification
From: Chinese Journal of Urology 2021;42(12):950-953
CountryChina
Language:Chinese
Abstract: Microphthalmia-associated transcription (MiT) family translocation related renal cell carcinoma (RCC) is an important type of renal cell carcinoma, which was included in the new classification of renal tumors by the World Health Organization (WHO) as an independent subtype in 2016. This type of renal cell carcinoma mainly includes Xp11.2 translocation /TFE3 gene fusions associated with renal cell carcinoma and T (6; 11)(p21; q12)/TFEB gene fusion-associated renal cell carcinoma, which has similar clinical features, histology, immunohistochemistry, and molecular genetics, but is significantly different from other renal cell carcinomas. In this review, the clinicopathology and genetics of MiT family translocation associated renal cell carcinoma were reviewed in order to provide guidance and help to the clinical and pathologic work.