The progress on the mechanism of NLRP3 inflammasome in renal ischemia-reperfusion injury
10.3760/cma.j.cn112330-20200828-00632
- VernacularTitle:肾缺血再灌注损伤中NLRP3炎症小体作用机制的研究进展
- Author:
Qiang YUAN
1
;
Kaiwen SHEN
;
Ruibo ZHANG
;
Jun SHEN
Author Information
1. 贵州医科大学附属医院泌尿外科，贵阳 550004
- Keywords:
Reperfusion injury;
Renal ischemia-reperfusion injury;
NLRP3-inflammasome;
Inflammasome
- From:
Chinese Journal of Urology
2021;42(7):554-558
- CountryChina
- Language:Chinese
-
Abstract:
Renal ischemia-reperfusion injury often occurs during operations that need to block the blood supply of the kidneys. It is an important pathophysiological process that affects the recovery of kidney function and causes acute renal failure. Activated NLRP3 inflammasome can mediate the maturation and release of a variety of pro-inflammatory factors, and participate in the inflammatory response in renal ischemia-reperfusion injury, thereby regulating body inflammation and related cell functions. This article summarized how NLRP3 inflammasome mediated the occurrence of inflammation in renal ischemia reperfusion injury, and further provied a new basis for the prevention and treatment of renal ischemia-reperfusion injury.
