A resting-state fMRI comparative study on bladder storage function between normal volunteers and neurogenic overactive bladder
10.3760/cma.j.cn112330-20210414-00194
- VernacularTitle:神经源性膀胱过度活动症患者膀胱储尿期大脑功能连接的研究
- Author:
Yi GAO
1
;
Limin LIAO
;
Xiaoqian YING
Author Information
1. 中国康复研究中心北京博爱医院泌尿外科 首都医科大学康复医学院，北京 100068
- Keywords:
Magnetic resonance imaging;
Brain control;
Overactive bladder;
Neurogenic bladder;
Urine storage;
Resting state magnetic resonance imaging
- From:
Chinese Journal of Urology
2021;42(6):430-435
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe central responses and functional connectivity (FC) during urinary bladder storage in neurogenic overactive bladder (NOAB).Methods:Twenty patients with NOAB were recruited. Resting state functional magnetic resonance imaging (rs-fMRI)were performed in all subjects under the following two conditions: empty bladder state and full bladder (strong desire to void)state. Software MATLAB, SPM8 and DPABI were adopted to analyze the difference of brain imaging between the two conditions. Voxel-based analysis of the REHO was performed to analyze rs-fMRI data including the main excitatory regions and inhibitory areas, peak value(X-axis, Y-axis, Z-axis), clusters size (active volume unit: number of voxel), T value(the excitatory and inhibitory extent of brain active regions). Voxel-based analysis of the REHO maps and FC between empty and full bladder were performed.Results:Increased activity during strong desire to void with NOAB patients was observed in the left orbital part of superior frontal, right middle frontal gyrus, and right superior frontal. Decreased activity was observed in right precentral. FC analysis found that these activated or deactivated brain regions were widely connected with other brain areas, include: frontal lobe, parietal lobe, temporal lobe, cingulate gyrus, lenticular nucleus, insular lobe, angular gyrus, parahippocampal gyrus and anterior and posterior central gyrus.Conclusions:Our results suggested that the right frontal robe may play a role in the control of bladder with NOAB during strong desire to void, and inhibitory areas located in right precentral. In NOAB patients, excitatory and inhibitory connections were increased in frontal lobe and central gyrus, decreased in insular lobe and parhippocampal gyrus.
