Structural and functional changes and their cellular and molecular mechanisms during cardiac senescence
10.3760/cma.j.issn.0254-9026.2021.11.021
- VernacularTitle:心脏衰老过程中结构和功能的变化及其细胞和分子作用机制
- Author:
Mingjing YAN
1
;
Jian LI
;
Tao SHEN
Author Information
1. 北京医院 国家老年医学中心 国家卫生健康委北京老年医学研究所 国家卫生健康委北京老年医学重点实验室 中国医学科学院老年医学研究院 北京大学第五临床医学院 100730
- Keywords:
Heart;
Aging;
Oxidative stress;
Mitochondrial
- From:
Chinese Journal of Geriatrics
2021;40(11):1437-1443
- CountryChina
- Language:Chinese
-
Abstract:
Cardiac senescence can change the structure and function of the heart and increase the risk of cardiovascular disease.Cardiac senescence is not only closely related to telomere damage, oxidative stress, mitochondrial dysfunction and autophagy, but also is regulated by non-coding RNA.Therefore, this article will give an overview of cardiac senescence and relative pathogenetic mechanisms, in order to provide new ideas for preventing and treating cardiac senescence and for achieving healthy and longevity.
