Clinical significance of serum glial fibrillary acidic protein level in middle-aged and elderly patients with Parkinson's disease
10.3760/cma.j.issn.0254-9026.2021.11.007
- VernacularTitle:中老年帕金森病患者血清胶质纤维酸性蛋白浓度变化的临床意义
- Author:
Jingying YU
1
;
Yue LOU
;
Miao CAI
;
Siran ZHANG
;
Ting ZHAO
;
Yan LI
;
Xinyu CHEN
Author Information
1. 浙江大学医学院附属浙江医院神经内科，杭州 310000
- Keywords:
Parkinson's disease;
Glial fibrillary acidic protein;
Cognition
- From:
Chinese Journal of Geriatrics
2021;40(11):1372-1375
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical significance of serum glial fibrillary acidic protein(GFAP)level in middle-aged and elderly patients with Parkinson's disease(PD).Methods:In the prospective study, a total of 39 patients with PD hospitalized in the Department of Neurology of Zhejiang Hospital affiliated to Zhejiang University School of Medicine, and 17 healthy subjects from January 2017 to May 2021 were collected.Serum GFAP levels in the PD group and healthy control(CT)group were detected by an ultra-sensitive Simoa hypersensitive protein detection technology.The correlations of serum GFAP level with age, gender, clinical presentation type, depression score, Montreal Cognitive Assessment Scale(MOCA)score and Mini-Mental State Examination(MMSE)score were analyzed.Results:The level of serum GFAP was significantly higher in PD group(219.6±166.2)ng/L than in CT group(109.9±56.6)ng/L( P< 0.01). In PD group, there was no correlation of serum GFAP with age, gender, clinical classification, depression and MOCA score(age: r=0.042, gender: r=-0.142, depression score: r=0.076, MoCA score: r=0.014, all P>0.05); but there was a significant negative correlation between serum GFAP and MMSE score( r=-0.433, P< 0.05). Conclusions:There is a negative correlation between serum GFAP level and MMSE score, suggesting that the increase of serum GFAP might be suggestive of cognitive decline in Parkinson's disease patients to some extent, which should be paid attention to in clinical work.
