An intervention study on the effects of vitamin D 3 on cognitive function and blood inflammatory cytokines in patients with Alzheimer's disease
10.3760/cma.j.issn.0254-9026.2021.11.004
- VernacularTitle:维生素D 3对阿尔茨海默病患者认知功能及外周炎性因子的干预研究
- Author:
Jingya JIA
1
;
Ying XIONG
;
Chong CHEN
;
Keran DUAN
;
Tong YANG
;
Hualou WANG
;
Fei MA
Author Information
1. 天津医科大学公共卫生学院流行病与卫生统计学系 300070
- Keywords:
Alzheimer disease;
Vitamin D;
Inflammatory cytokines;
Cognitive function
- From:
Chinese Journal of Geriatrics
2021;40(11):1357-1362
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the effects of a 12-month vitamin D 3 intervention on cognitive function and blood inflammatory cytokines in subjects with Alzheimer's disease(AD). Methods:Two hundred and ten AD patients were randomly divided into the intervention and control groups, with 105 patients in each group.The intervention group received vitamin D 3 800 U/day and the control group received a placebo for 12 months.Repeated-measures analysis of variance was used to evaluate the effects of vitamin D and placebo on cognitive performance and blood inflammatory cytokines at baseline, month 6 and month 12. Results:During the follow-up, serum 25(OH)D 3( F=712.086, P<0.001)and 1, 25(OH) 2D 3( F=372.038, P<0.001)concentrations in the intervention group were significantly higher than those in the control group.Changes in FSIQ, VIQ and PIQ between the groups, between different time points and with interaction between the variables taken into account were statistically significant(all P<0.001). Compared with the control group, interleukin-6(IL-6)( F=341.344, P<0.001)and tumor necrosis factor-α(TNF-α)( F=9.580, P<0.001)levels in the intervention group were significantly decreased, and the ratio of Aβ40 to Aβ42 was increased( F=4.617, P=0.010). There were interaction effects between group and time.Except for intervention effects, the baseline concentration of 25(OH)D 3 was positively correlated with scores of FSIQ( β=0.016, P=0.031)and VIQ( β=0.017, P=0.031). Conclusions:Daily oral vitamin D 3 supplementation(800 U/day)for 12 months may improve cognitive function and change inflammatory cytokines in elderly patients with AD.
