Progress in research on autophagy in vascular aging-related diseases
10.3760/cma.j.issn.0254-9026.2021.10.021
- VernacularTitle:自噬在血管衰老相关疾病中的研究进展
- Author:
Hui PAN
1
;
Huafang LIU
;
Li WANG
;
Xiao WANG
Author Information
1. 中国人民解放军中部战区总医院干部病房二科，武汉 430070
- Keywords:
Vascular aging;
Autophagy;
Age-related diseases
- From:
Chinese Journal of Geriatrics
2021;40(10):1317-1322
- CountryChina
- Language:Chinese
-
Abstract:
Aging begins in the early stages of life and is an irreversible process in which wide-ranging and gradual functional declines occur with age in various organs of the body.Vascular aging, as a part of the overall aging process, plays an important role in the occurrence and development of vascular senescence-related diseases.Autophagy maintains homeostasis of the intracellular environment via degradation of damaged, denatured, or senescent proteins and organelles.Studies have found that basal autophagy is critical in regulating normal vascular function.However, abnormal autophagy may contribute to vascular aging and diseases associated with it.The purpose of this paper is to review recent progress on autophagy in vascular aging and its related diseases.
