Research progress on the role of the Wnt signaling pathway in the development of intrauterine adhesions and its significance in treatment
10.3760/cma.j.issn.0254-9026.2021.06.024
- VernacularTitle:Wnt信号通路在宫腔粘连纤维化形成及治疗中的研究进展
- Author:
Xiaoning WEI
1
;
Shaowei WANG
Author Information
1. 中国医学科学院北京协和医学院研究生院，北京 100730
- Keywords:
Intrauterine Adhesions;
Wnt Proteins
- From:
Chinese Journal of Geriatrics
2021;40(6):803-806
- CountryChina
- Language:Chinese
-
Abstract:
The Wnt signaling pathway also plays a role in fibrotic diseases of various tissues and organs, such as pulmonary fibrosis, liver fibrosis, renal fibrosis and skin fibrosis.Activation of the Wnt signaling pathway is related to the fibrosis of the endometrium and ectopic endometrial tissue, and it is a key component of the potential mechanisms for the development intrauterine adhesions.It could also be a target for treatment via promoting endometrial proliferation and angiogenesis and enhancing colony formation and self-renewal ability of endometrial stem cells.Wnt signaling pathways may regulate the complicated cross-talking networks and balance the dynamic processes of fibrogenesis and repair in intrauterine adhesions, thus potentially providing a new route for studying the pathological mechanisms of intrauterine adhesions and finding therapeutic targets.
