Advances in the study of biological age in healthy aging
10.3760/cma.j.issn.0254-9026.2021.06.023
- VernacularTitle:生物学年龄在健康老龄化中的研究进展
- Author:
Chen CHEN
1
;
Ying ZHANG
;
Ruiyue YANG
;
Qi ZHOU
;
Xianghui LI
;
Ze YANG
;
Liang SUN
Author Information
1. 北京医院 国家老年医学中心 国家卫生健康委北京老年医学研究所 国家卫生健康委北京老年医学重点实验室 中国医学科学院老年医学研究院 100730
- Keywords:
Biological age;
Aging biomarkers;
Statistical model
- From:
Chinese Journal of Geriatrics
2021;40(6):798-802
- CountryChina
- Language:Chinese
-
Abstract:
Population aging increases the demand for human aging research and its clinical applications.Traditionally, the chronological age(CA), that is, the age based on the calendar, is used to describe the state of aging.However, the aging process and speed among individuals are not consistent and often show clear individual differences in biological aging.Therefore, CA cannot truly reflect people's conditions of body structure and function, has drawbacks leading to unreliable and wrong assessment, and is unable to accurately describe the human body's state of aging.In recent years, it has been proposed that the biological age(BA)should be used to more comprehensively and accurately describe the stage of human aging.Combining mathematical algorithms with a variety of biomarkers, predictive models can be constructed to quantify BA.These approaches have been increasingly appreciated for their improved accuracy and received further investigation.This article reviews the value of BA, currently commonly used calculation methods and their progress and prospects in healthy aging.
