Lowering the cut-off value of ALT may contribute to identify chronic HBV infection patients with significant liver histological changes
10.3760/cma.j.issn.1674-2397.2021.04.005
- VernacularTitle:下调ALT正常值上限有利于识别国内存在肝组织学显著改变的ALT正常慢性HBV感染者
- Author:
Bo WANG
1
;
Li XIAO
;
Yang LI
;
Hongtao XU
;
Jianchun XIAN
Author Information
1. 南通大学第五附属医院（江苏省泰州市人民医院）肝病科，泰州 225300
- Keywords:
Chronichepatitis B;
Liver biopsy;
Alanine transaminase
- From:
Chinese Journal of Clinical Infectious Diseases
2021;14(4):280-285
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the necessity of lowering the cut-off value of alanine aminotransferase (ALT) in identifying chronic HBV infection patients with significant liver histological changes.Methods:The clinical data of 123 chronic HBV infection patients with normal ALT according to domestic criteria who underwent liver biopsy in the Department of Hepatology of Taizhou People’s Hospital from June 2016 to March 2021 were analyzed retrospectively. According to the cut-off ALT values recommended by 2018 version of AASLD guidelines (male 35 U/L, female 25 U/L), the patients were divided into two groups: high normal value group (HNALT, ALT≥AASLD and
