Advances on roles of Th22 cells in human common viral infections
10.3760/cma.j.issn.1674-2397.2021.03.015
- VernacularTitle:Th22细胞在人类常见病毒感染中的研究进展
- Author:
Dawei CUI
1
;
Ni YAO
;
Yan LV
;
Wenwen WU
;
Dandan XU
;
Jue XIE
Author Information
1. 浙江大学医学院附属第一医院输血科，杭州 310003
- Keywords:
T-lymphocytes, helper-inducer;
Communicable diseases;
Virus;
Th22 cells;
Interleukin-22
- From:
Chinese Journal of Clinical Infectious Diseases
2021;14(3):233-240
- CountryChina
- Language:Chinese
-
Abstract:
Na?ve CD4 + T cells differentiate into a variety of T helper (Th) subsets that secrete various cytokines to exert biological effects. Th22 cells, a novel identified CD4 + T cell subset, are distinct from Th1, Th2 and Th17 cell subsets. Th22 cells express chemokine receptors CCR4, CCR6 and CCR10, and secrete multiple cytokines such as IL-22, IL-13 and TNF-α, but not IL-17, IL-4 IFN-γ; and IL-22 is considered as major effector cytokine of Th22. The understanding on functions and differentiation mechanisms of Th22 cells have been constantly improved, and Th22 cells play important roles in human common viral infections. The article reviews the current advances about the characteristics, function, differentiation of Th22 cells, the roles of Th22 cells and the key molecules in several human common viral infections, which would provide novel immune strategies for the prevention and treatment of human viral infection.
