The therapeutics and management of cryptococcus-related immune reconstitution inflammatory syndrome in AIDS patients
10.3760/cma.j.issn.1674-2397.2021.03.013
- VernacularTitle:AIDS患者隐球菌相关免疫重建炎症综合征的治疗和管理
- Author:
Jiangjin HUI
1
;
Biao ZHU
Author Information
1. 浙江大学医学院附属第一医院感染病科，传染病诊治国家重点实验室，感染性疾病诊治协同创新中心，国家临床医学研究中心，杭州 310006
- Keywords:
Acquired immune deficiency syndrome;
Cryptococcosis;
Immune reconstitution inflammatory syndrome;
Therapeutics;
Management
- From:
Chinese Journal of Clinical Infectious Diseases
2021;14(3):222-227
- CountryChina
- Language:Chinese
-
Abstract:
Acquired immune deficiency syndrome (AIDS) can cause various opportunistic infections clinically due to severe defects in the body’s cellular immune function. Cryptococcosis is a common serious opportunistic infection in AIDS patients. With the promotion and popularization of high activity antiretroviral therapy (HAART) programs worldwide, the mortality rate of AIDS-related cryptococcosis has been significantly decreased. After initiating antiviral therapy, some patients experienced recurrence and aggravation of clinical symptoms during anti-cryptococcal treatment. The body has an inflammatory response to the excessive immune regulation of cryptococcal antigens, which is called cryptococcus-related immune reconstitution inflammatory syndrome (C-IRIS). C-IRIS seriously affects the quality of life and prognosis of patients. This article reviews the clinical features, pathogenesis and the latest treatment and management strategies of C-IRIS in AIDS patients.
