Serum chromogranin A (CGA) level in predicting the prognosis of severe hand, foot, and mouth disease complicated with neurogenic pulmonary edema
10.3760/cma.j.issn.1674-2397.2021.03.003
- VernacularTitle:嗜铬粒蛋白A水平在预测重症手足口病并发神经源性肺水肿患儿预后中的意义
- Author:
Junhao CUI
1
;
Chunlan SONG
;
Lin ZHU
;
Peng LI
Author Information
1. 郑州大学附属儿童医院 河南省儿童医院 郑州儿童医院重症监护室 450000
- Keywords:
Chromogranin A;
Severe hand, foot and mouth disease;
Neurogenic pulmonary edema;
Interleukin 6
- From:
Chinese Journal of Clinical Infectious Diseases
2021;14(3):179-183
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical significance of serum Chromogranin A (CGA) level in predicting the prognosis of children with severe hand, foot, and mouth disease (HFMD) and complicating neurogenic pulmonary edema (NPE).Methods:A total of 162 patients with HFMD admitted in our hospital from January 2017 to December 2019 were enrolled in the study; and 40 age-matched healthy children were selected as controls. According to the disease severity and complication the patients were divided into three groups: mild group ( n=88), severe without NPE group ( n=46) and severe with NPE group ( n=28). In 72 severe HFMD patients 16 cases died (fatal group) and 56 cases survived (survival group) within 28 days of hospitalization. The serum CGA, LAC, GLU, WBC, PCT, IL-6, cTnT were measured in all subjects. SPSS 23.0 software was used for data analysis, and the receiver operating characteristic (ROC) curve was used to evaluate the various indicators for predicting the prognosis of severe HFMD combined with NPE. Results:The serum CGA, GLU, LAC, IL-6 and cTnT levels in severe HFMD group with NPE significantly higher than those in the other three group ( H=61.554, 79.031, 86.994, 36.477, 75.021, all P<0.05 ). The serum CGA, LAC, GLU and IL-6 levels in the fatal group were significantly higher than those in survival group ( Z=-6.094, -4.621, -4.283, -5.504, all P<0.05). There was no significant difference in the levels of WBC, PCT and cTnT between the survival group and the fatal group ( P>0.05). The area under the receiver operating curve (AUC) of serum CGA was 0.890 (95% CI: 0.833-0.947) for predicting the prognosis of patients and the best cut-off value was 120.59 μg/L. Conclusion:The detection of serum CGA levels may be beneficial for the early diagnosis of severe HFMD with NPE, and can be used as one of the predictors of death from severe HFMD.
