Clinical value of heparin binding protein level in BALF for diagnosis and differential diagnosis of bacterial pneumonia
10.3760/cma.j.issn.1674-2397.2021.02.007
- VernacularTitle:肺泡灌洗液肝素结合蛋白在细菌性肺炎诊断与鉴别诊断中的临床价值
- Author:
Huijuan BI
1
;
Jilu SHEN
;
Wenhao FANG
;
Shan WU
;
Lina YIN
;
Qian XU
;
Ying XUE
;
Chenyang KE
Author Information
1. 安徽医科大学第四附属医院检验科，合肥 230000
- Keywords:
Bronchoalveolar lavage fluid;
Pneumonia;
Heparin binding protein;
Procalcitonin;
Interleukin-6
- From:
Chinese Journal of Clinical Infectious Diseases
2021;14(2):116-120
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical value of heparin binding protein (HBP) in bronchoalveolar lavage fluid (BALF) for diagnosis and differential diagnosis of bacterial pneumonia.Methods:Eighty eight patients with pulmonary infection from the respiratory department of the Fourth Affiliated Hospital of Anhui Medical University from January 2019 to January 2021 were enrolled in the study, including 48 cases of bacterial pneumonia and 40 cases of non-bacterial pneumonia; meanwhile, 40 non-pulmonary infection patients were also enrolled as the control group. The BALF levels of HBP, procalcitonin (PCT), interleukin-6 (IL-6) were measured, and the clinical values of the above indexes in differential diagnosis of bacterial and non-bacterial pneumonia were analyzed.Results:The BALF levels of HBP and IL-6 in bacterial pneumonia group were significantly higher than those of the non-bacterial pneumonia group and the control group ( P<0.05). ROC curve showed that the areas under the curve (AUC) of HBP and IL-6 were 0.930 and 0.893 for the early diagnosis of bacterial pneumonia; and the sensitivity was 88.5% and 82.7%, the specificity was 92.5% and 92.5%, respectively. Combined detection of HBP and IL-6, the AUC was 0.942 and the sensitivity was 94.2% and the specificity was 95.0%. When they were used to distinguish bacterial pneumonia, the AUC of HBP and IL-6 were 0.890 and 0.777, and the sensitivities were 80.8% and 71.2%, and the specificity were 91.7% and 75.0%, respectively. Combined detection of HBP and IL-6, the AUC was 0.902, and the sensitivity was 96.2% and the specificity was 79.2%. Conclusions:BALF HBP and IL-6 have good clinical value in the early diagnosis and distinguishing bacterial pulmonary infection and the joint value of the two is better.
