The interaction between 2019-nCoV and interferon Ⅰ
10.3760/cma.j.issn.1674-2397.2021.02.004
- VernacularTitle:2019-nCoV与Ⅰ型干扰素的博弈
- Author:
Jun GUAN
1
;
Zhi CHEN
;
Haihong ZHU
Author Information
1. 浙江大学医学院附属第一医院传染病诊治国家重点实验室、国家感染性疾病临床医学研究中心、感染性疾病诊治协同创新中心，杭州 310003
- Keywords:
2019-nCoV;
COVID-19;
Type Ⅰ interferon;
Innate immunity;
Immune evasion
- From:
Chinese Journal of Clinical Infectious Diseases
2021;14(2):97-101
- CountryChina
- Language:Chinese
-
Abstract:
COVID-19 has swept across the world, causing widespread epidemics and millions of life lost worldwide. After infected with 2019-nCoV, the body quickly mobilizes the innate immune response and produces type Ⅰ interferon (IFN-Ⅰ). IFN-Ⅰ plays an important role in virus clearance in the early stage of disease. This article reviews the innate immune recognition after virus infection and the interaction between 2019-nCoV and IFN-Ⅰ, which would be conductive to understanding the pathogenesis and antiviral treatment of COVID-19.
