Association between plasma IgG N-glycan profiling and suboptimal health status among undergraduates in a college in Shandong Province
10.3760/cma.j.cn115624-20210206-00068
- VernacularTitle:山东某高校新生亚健康状态与血浆免疫球蛋白G N-糖基组的相关性
- Author:
Xiaoni MENG
1
;
Hao WANG
;
Hongqi LIU
;
Xizhu XU
;
Manshu SONG
;
Youxin WANG
Author Information
1. 首都医科大学公共卫生学院流行病与卫生统计学系，临床流行病学北京市重点实验室，北京 100069
- Keywords:
Suboptimal health status;
Immunoglobulin G;
N-glycans;
Biomarkers
- From:
Chinese Journal of Health Management
2021;15(5):452-458
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between suboptimal health status (SHS) and plasma IgG N-glycans levels among undergraduates in a college in Shandong Province.Methods:A case-control study was conducted from September to November 2017, 100 college students who underwent physical examinations at Weifang University in Shandong, were selected as study participants based on the inclasion and exclusion criteria of the study. According to the criteria of SHS, the participants were divided into an SHS group ( n=50) and a health control group ( n=50). Plasma IgG N-glycosylaton levels were analyzed by means of ultra-high liquid chromatography (UPLC), and 24 glycan peaks were obtained. The Mann-Whitney U-test and binary logistic regression analysis were performed to investigate the association between IgG N-glycans and SHS. P<0.05 was considered statistically significant. Receiver operating characteristic (ROC) curve analyses were used to evaluate the possibility of plasma IgG N-glycans being a biomarker of SHS. Results:The results of univariate and multivariate analysis showed that GP17 was associated with SHS ( P<0.05), and the relative abundance of initial glycan peaks (GP17) was higher in the SHS group compared with the control group. ROC curve analysis showed that the area under the curve (AUC) of the baseline model was 0.826 (95% confidence interval [ CI]: 0.747-0.905, P<0.001); the AUC of the glycan-based model was 0.631 (95% CI: 0.519-0.744, P=0.002), and the AUC of the combined model was 0.848 (95% CI: 0.763-0.912, P<0.001). Compared with the baseline model, the diagnostic efficiency of the combined model revealed a trend of improvement. Conclusions:The SHS of the students in a college in Shandong Province was associated with an IgG N-glycan level of GP17, which was significantly higher than that of the control group.
