Quantitative computed tomography-derived abdominal visceral adipose tissue and cardiometabolic risk in a large-scale population
10.3760/cma.j.cn115624-20201228-00893
- VernacularTitle:定量CT测量的腹部内脏脂肪与心血管代谢风险的相关性
- Author:
Shengyong DONG
1
;
Xiaojuan ZHA
;
Limei RAN
;
Yongli LI
;
Shuang CHEN
;
Jianbo GAO
;
Shaolin LI
;
Yong LU
;
Yuqin ZHANG
;
Xiao MA
;
YueHua LI
;
Xigang XIAO
;
Xiangyang GONG
;
Zehong YANG
;
Wei CHEN
;
Yingying YANG
;
Bairu CHEN
;
Yingru LYU
;
Yan WU
;
Jing WU
;
Kaiping ZHAO
;
Xiaoxia FU
;
Xia DU
;
Haihong FU
;
Xiaoguang CHENG
;
Qiang ZENG
Author Information
1. 解放军总医院第二医学中心健康管理研究院，北京 100853
- Keywords:
Abdominal fat;
Visceral adipose tissue;
Cardiometabolic risk;
Quantitative computed tomography
- From:
Chinese Journal of Health Management
2021;15(5):425-431
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between abdominal visceral adipose tissue (VAT) and cardiometabolic risk (CMR) through quantitative computed tomography (QCT).Methods:The present study included 76226 participants. Abdominal fat areas were measured using the QCT Pro Model 4 system. Cardiometabolic indices were collected, including systolic and diastolic blood pressures, fasting plasma glucose, total cholesterol, triglyceride, and low-density and high-density lipoprotein cholesterols CMR score was the sum of abnormal blood pressure, fasting glucose, triglyceride, and high-density lipoprotein cholesterol. Restricted cubic spline and ordered logistic regression models were applied.Results:The mean age was 50±13 years and the percentage of men was 58.8%. The level of VAT area was higher in men than in women (191.7±77.1 cm 2 vs 116.4±56.2 cm 2, P<0.0001 for all). After adjustment for age, the cardiometabolic indices except high-density lipoprotein cholesterol increased with increasing VAT area. When VAT area was 300 cm 2, age-adjusted odds ratios and 95% confidence intervals of a CMR score ≥ 1 were 14.61 (13.31, 16.04) for men and 5.46 (4.06, 7.36) for women, and the age-adjusted probability of a CMR score ≥ 3 was 31.7% for men and 31.3% for women. Conclusions:QCT-derived VAT is closely related to CMR. The findings suggest that measurement of visceral fat is recommended for the management of abdominal obesity in subjects who agree to undergo lung cancer screening via low-dose CT without additional radiation exposure.
