Application of radionuclide imaging in the diagnosis and management of Gaucher′s disease
10.3760/cma.j.cn321828-20200408-00141
- VernacularTitle:核素显像在戈谢病诊治中的应用价值
- Author:
Zhixin HAO
1
;
Zhengqing QIU
;
Bing HAN
;
Xiuchun JIANG
;
Li HUO
;
Shuyang ZHANG
Author Information
1. 中国医学科学院、北京协和医学院北京协和医院核医学科、核医学分子靶向治疗北京市重点实验室 100730
- Keywords:
Gaucher disease;
Technetium Tc 99m sestamibi;
Technetium Tc 99m medronate;
Deoxyglucose;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2021;41(10):628-631
- CountryChina
- Language:Chinese
-
Abstract:
Gaucher′s disease (GD) is a lysosomal storage disease, and the etiology of GD is the decreased activity of glucocerebrosidase, which leads to the accumulation of glucocerebroside in the lysosomes of macrophages. Because GD is rare and lacks specific clinical manifestations, it is easy to be misdiagnosed, which delays the best time for treatment. Early diagnosis, clinical evaluation, and regular monitoring of the disease have important clinical significance for enzyme replacement therapy in patients with GD. Recent studies have found that radionuclide imaging is playing an increasingly important role in the diagnosis and treatment of GD. This article introduces the application of radionuclide imaging in the diagnosis and management of GD.
