Progress of α ray labeled probes in tumor targeted radionuclide therapy
10.3760/cma.j.cn321828-20200407-00139
- VernacularTitle:α射线肿瘤核素靶向治疗新进展
- Author:
Weidong YANG
1
;
Jing WANG
Author Information
1. 空军军医大学第一附属医院核医学科，西安 710032
- Keywords:
Radiotherapy;
Alpha particles;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2021;41(9):558-561
- CountryChina
- Language:Chinese
-
Abstract:
As an effective treatment for tumor, the radionuclide targeting therapy is developing rapidly. Radionuclides produced β ray or α ray can be used for labeling tumor targeting probes. Compared with β ray, α ray has higher linear energy transfer, which can destroy DNA more effectively and kill tumor cells thoroughly. Besides, the tissue penetration distance of α ray is short, which can reduce the damage to normal tissue. In recent years, α ray radionuclides are more and more used in tumor targeted therapy. A variety of probes have been labeled with different α ray radionuclides and used in the treatment of hematological malignancies, neuroendocrine neoplasms, prostate cancer, melanoma, etc. This article summarizes the progress of α ray radionuclides and their labeled probes in tumor treatment.
