Predictive value of TgAb for disease status in differentiated thyroid cancer patients with stimulated Tg<1 μg/L during postoperative assessment
10.3760/cma.j.cn321828-20200514-00193
- VernacularTitle:TgAb在术后评估中对刺激性Tg<1 μg/L分化型甲状腺癌患者疾病状态的预测价值
- Author:
Si ZHOU
1
;
Ruping LI
;
Lijun WANG
;
Kai CHEN
;
Xianmin DING
;
Sen WANG
;
Zhansheng ZHANG
;
Jianmin JIA
;
Hui YANG
Author Information
1. 郑州大学附属肿瘤医院、河南省肿瘤医院核医学科 450003
- Keywords:
Thyroid neoplasms;
Surgical procedures, operative;
Radiotherapy;
Iodine radioisotopes;
Thyroglobulin;
Antibodies;
Forecasting
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2021;41(9):540-543
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the association between thyroglobulin antibody (TgAb) and differentiated thyroid cancer (DTC) metastases detected by post-radioactive iodine (RAI) therapy scan, when stimulated thyroglobulin (sTg) <1 μg/L.Methods:A total of 314 (68 males, 246 females, age (44.5±12.5) years) post-thyroidectomy DTC patients whose sTg <1 μg/L between March 2013 and May 2017 in Henan Cancer Hospital were enrolled retrospectively. Patients underwent 131I whole-body planar imaging ( 131I-WBS) and SPECT/CT imaging 5 d after 131I administration. Iodine avid metastases were compared between TgAb-positive group and TgAb-negative (TgAb<4 kU/L) group. Logistic regression analysis was conducted to assess odds ratio ( OR) for iodine avid metastases in each subgroup (Q1: 4 kU/L≤TgAb≤9.27 kU/L; Q2: 9.27 kU/L101.43 kU/L) of TgAb-positive patients, with the TgAb-negative patients as the reference. χ2 test was used to analyze the data. Results:Iodine avid metastases were found in 16.9% (53/314) of DTC patients and were more frequently in TgAb-positive group with TgAb>26.75 kU/L than TgAb-negative group (26.0%(19/73) vs 13.7%(23/168); χ2=5.382, P=0.02). Most metastases (92.5%, 49/53) occurred in cervical and mediastinal lymph nodes. The OR for iodine avid metastases was obviously high in TgAb-positive patients with 26.75 kU/L
