Research progress of tertiary lymphoid structure on hepatocellular carcinoma
10.3760/cma.j.cn113884-20210530-00186
- VernacularTitle:三级淋巴结构在肝癌中的研究进展
- Author:
Tianchen ZHANG
1
;
Xinjun LEI
;
Zhenzhen MAO
;
Jianhui LI
;
Ye NIE
;
Yanfang WANG
;
Wenjie SONG
Author Information
1. 西安医学院 710021
- Keywords:
Carcinoma, hepatocellular;
Tertiary lymphoid structure;
Tumor microenvironment;
Immune infiltration;
Immunotherapy
- From:
Chinese Journal of Hepatobiliary Surgery
2021;27(11):871-874
- CountryChina
- Language:Chinese
-
Abstract:
Tertiary lymphoid structure (TLS) is the ectopic lymphoid tissue around the chronic inflammatory site of tumor, infection diseases, autoimmunity diseases, organ transplantation and so on. TLS is regarded as the vital niche of antitumor immune response in tumor microenvironment for abundant immune cells, and is correlated with better clinical outcomes and immunotherapy response in most solid tumors. As a typical inflammation-driven cancer, hepatocellular carcinoma (HCC) is controversial with the influence of TLS on patients prognosis. In this paper, the composition, formation mechanism, recognition and clinical value of TLS in HCC were briefly reviewed.
