Research progress on ferroptosis and fatty liver ischemia-reperfusion injury
10.3760/cma.j.cn113884-20210410-00131
- VernacularTitle:铁死亡与脂肪肝缺血再灌注损伤相关靶点研究进展
- Author:
Xiang LI
1
;
Hongli SONG
Author Information
1. 天津医科大学一中心临床学院 300192
- Keywords:
Fatty liver;
Reperfusion injury;
Liver transplantation;
Ferroptosis
- From:
Chinese Journal of Hepatobiliary Surgery
2021;27(10):786-789
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a new type of cell death proposed in recent years. It refers to the excessive accumulation of reactive oxygen species under iron dependence, which leads to fatal lipid peroxidation of cells and ultimately leads to cell death. Fatty liver is extremely sensitive to ischemia-reperfusion injury and poorly tolerated. It’s still not understood well, and the therapeutic options are limited for the fatty liver patients. The pathophysiological characteristics of ferroptosis and fatty liver ischemia-reperfusion injury are similar, and the discovery of ferroptosis may provide a new treatment strategy for fatty liver to prevent ischemia-reperfusion injury. This article mainly reviews the mechanism of ferroptosis and the targets related to ferroptosis in fatty liver ischemia-reperfusion injury.
