Gender-Specific Association of the Brain-Derived Neurotrophic Factor Gene with Attention-Deficit/Hyperactivity Disorder.
- Author:
Soo Churl CHO
1
;
Hyo Won KIM
;
Boong Nyun KIM
;
Jae Won KIM
;
Min Sup SHIN
;
Seockhoon CHUNG
;
Dae Yeon CHO
;
Sun Woo JUNG
;
Hee Jeong YOO
;
In Won CHUNG
;
Un Sun CHUNG
;
Jung Woo SON
Author Information
1. Department of Child and Adolescent Psychiatry, Seoul National University College of Medicine, Seoul, Korea. shingubi@gmail.com
- Publication Type:Original Article
- Keywords:
Association studies;
Attention-deficit/hyperactivity disorder;
Brain-derived neurotrophic factor;
Continuous performance test;
Single nucleotide polymorphism
- MeSH:
Adrenergic Neurons;
Brain-Derived Neurotrophic Factor;
Case-Control Studies;
Genotype;
Haplotypes;
Multivariate Analysis;
Polymorphism, Single Nucleotide
- From:Psychiatry Investigation
2010;7(4):285-290
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder with a strong genetic component. Brain-derived neurotrophic factor (BDNF), which participates in the differentiation and survival of dopaminergic and noradrenergic neurons, could play a role in ADHD development. We aimed to explore the relationships between ADHD and BDNF gene polymorphism. METHODS: We conducted a case-control analysis of 202 ADHD subjects and 159 controls, performed a transmission disequilibrium test on 151 trios, and compared the results of a continuous performance test (CPT) according to the genotype of the three single nucleotide polymorphisms (rs11030101, rs6265, rs16917204) in the BDNF gene. RESULTS: In the case-control analysis, the AA genotype of the BDNF rs11030101 polymorphism was significantly associated with ADHD only in girls (p=0.024, odds ratio=3.00). The T-G-G haplotype was significantly less frequent (p=0.005) and A-G-G was more frequent (p=0.048) in girls with ADHD than in control girls (global p=0.027). A multivariate analysis of variance for commission errors on the CPT showed a significant main effect for the rs11030101 genotype (p=0.026) and an interaction effect of the rs11030101 genotype and gender (p=0.032) in ADHD probands. CONCLUSION: These results provide preliminary evidence for a gender-specific association between BDNF and ADHD in the Korean population.
