Multi-slice CT imaging features as risk factors in determining spontaneous rupture of primary liver cancer
10.3760/cma.j.cn113884-20201210-00619
- VernacularTitle:基于多层螺旋CT影像特征原发性肝癌自发性破裂出血危险因素分析
- Author:
Kun LIN
1
;
Zhiling GAO
;
Guanhua YANG
;
Lin DENG
;
Tao REN
;
Yong CHEN
Author Information
1. 宁夏医科大学临床医学院，银川 750004
- Keywords:
Liver neoplasms;
Primary;
Rupture;
Risk factors;
Multi-slice computed tomography
- From:
Chinese Journal of Hepatobiliary Surgery
2021;27(9):658-662
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the imaging features of spontaneous rupture of primary liver cancer (PLC) and to study the high-risk factors associated with tumor rupture.Methods:From September 2016 to August 2020, 81 patients who developed spontaneous rupture of PLC at the General Hospital of Ningxia Medical University were included into this study. A control group of 81 patients with tumors located on the periphery of the liver but without rupture treated in the same period were selected by matching the two groups with age, sex and BCLC staging. The clinical data and CT imaging characteristics including tumor location, extent, size, and morphology of the two groups of patients were compared retrospectively between groups.Multivariate logistics regression was used to analyze.Results:A total of 81 patients were included in the case group, including 72 males and 9 females, aged (53.69±10.34) years. The control group included 81 patients, 64 males and 17 females, aged (54.78±9.04) years. The main risk factors for spontaneous rupture of PLC included in this study were cirrhosis, tumor close to diaphragm, biolobar distribution, portal vein obstruction, tumor diameter >10 cm, invasion of liver capsule (arc-to-chord ratio>1) and tumor protrusion ≥25% ( P<0.05). Logistic regression analysis showed that cirrhosis ( OR=2.796, 95% CI: 1.721-10.834), portal vein obstruction ( OR=3.586, 95% CI: 1.272-10.107) and tumor protrusion (≥25%) ( OR=2.831, 95% CI: 1.668-22.210) were independent predictive factors of spontaneous rupture of PLC. Conclusion:Tumor protrusion≥25%, cirrhosis and portal vein obstruction were closely related to spontaneous rupture of PLC. They were independent risk factors in predicting rupture of primary liver cancer.
