Research progress of mitochondrial dysfunction in pancreatic diseases
10.3760/cma.j.cn113884-20200924-00509
- VernacularTitle:线粒体功能障碍在胰腺疾病中的研究进展
- Author:
Yonglang CHENG
1
;
Meizhou HUANG
;
Hao CHEN
;
Baolin QIAN
;
Zhiwei HUANG
;
Wenguang FU
Author Information
1. 西南医科大学附属医院肝胆外科，四川泸州 646000
- Keywords:
Mitochondria;
Pancreatic diseases;
Research progress;
Dysfunction
- From:
Chinese Journal of Hepatobiliary Surgery
2021;27(8):637-640
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondrial dysfunction is closely related to the occurrence and development of benign and malignant diseases of the pancreas. Mitochondrial membrane of the respiratory chain electron transfer and energy transfer plays an important role in maintaining normal cellular function. When the respiratory chain was disrupted, the oxidative stress was increased in the cell, and produced a large number of oxide intermediate products which target mitochondrial protein, DNA, etc, lead to mitochondrial dysfunction finally induced acute pancreatitis, pancreatic cancer and other diseases. In addition, mitochondrial homeostasis plays an indispensable role in maintaining the normal function of islet cells. This paper reviewed the research status of mitochondrial dysfunction in pancreatic diseases.
