A balance mediated by liver sinusoidal endothelial cells on liver regeneration and fibrosis
10.3760/cma.j.cn113884-20200625-00339
- VernacularTitle:肝窦内皮细胞介导肝再生与纤维化平衡的研究进展
- Author:
Bo YUAN
1
;
Siming QU
;
Hanfei HUANG
;
Zhong ZENG
Author Information
1. 昆明医科大学第一附属医院器官移植中心，昆明 650032
- Keywords:
Endothelial cells;
Hepatectomy;
Liver regeneration;
Liver fibrosis
- From:
Chinese Journal of Hepatobiliary Surgery
2021;27(7):545-548
- CountryChina
- Language:Chinese
-
Abstract:
Liver sinusoidal endothelial cells (LSECs) play a positive role in maintaining microcirculation of the liver to achieve liver homeostasis, and they also mediate a balance between regeneration and fibrosis in the process repair of liver injury. After acute liver injury, LSECs are the regulators of liver regeneration, while in chronic injury, abnormally activated LSECs promote development of liver fibrosis. In this paper, we summarized the recent progress in research on the balance between LSECs-mediated liver regeneration and fibrosis, with the aim to provide new ideas in treating liver fibrosis and promoting liver regeneration by targeting LSECs.
