Analysis of safety and efficacy of laparoscopic pancreaticoduodenectomy and open pancreaticoduodenectomy: propensity score matching analysis
10.3760/cma.j.cn113884-20200916-00496
- VernacularTitle:基于倾向性得分匹配腹腔镜与开腹胰十二指肠切除术安全性和疗效分析
- Author:
Zilong WU
1
;
Fen ZHOU
;
Linhuan LI
;
Shun CHEN
;
Fangming WANG
;
Jun WANG
;
Pin LYU
;
Gang LIANG
;
Bingzhang TIAN
;
Lixue ZHOU
;
Ye OU
Author Information
1. 湖南师范大学附属第一医院 湖南省人民医院肝胆外科，长沙 410005
- Keywords:
Laparoscopy;
Pancreaticoduodenectomy;
Safety
- From:
Chinese Journal of Hepatobiliary Surgery
2021;27(7):520-524
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the safety and efficacy of laparoscopic versus open pancreaticoduodenectomy.Methods:The clinical data of 989 patients who underwent pancreaticoduodenectomy at Hunan People's Hospital from January 2015 to December 2019 were analyzed retrospectively. There were 349 patients in the laparoscopic pancreaticoduodenectomy (LPD) group and 640 patients in the open pancreaticoduodenectomy (OPD) group. Propensity score matching (PSM) was used to match the baseline data of the two groups at a 1: 1 ratio. Data including operation time, intraoperative bleeding, postoperative hospital stay, bile leakage, pancreatic fistula and wound infection were compared between the two groups.Results:After PSM, there were 345 patients in each of the 2 groups. When the LPD group was compared with the OPD group, there were no significant differences in postoperative mortality, reoperation, intraoperative blood transfusion, pancreatic fistula, bile leakage, abdominal hemorrhage, abdominal abscess, severe complications, and pulmonary complication rates. The number of lymph node dissected, R 0 resection and overall survival rates between the two groups were also not significantly different ( P>0.05). However, the operation time of the LPD group (478.2±91.3) min was significantly longer than that of the OPD group (410.8±62.0) min ( P<0.05). On the other hand, the postoperative hospitalization time (10.8±4.3) d, intraoperative bleeding (322.0±362.6) ml, wound infection rate 1.2% (4/345) in the LPD group were significantly better than those in the OPD group [postoperative hospitalization time (12.5±7.9) d, intraoperative bleeding (478.8±570.2) ml, and wound infection rate 5.8% (20/345)] ( P<0.05) . Conclusion:LPD was safe and feasible, and it achieved similar curative effect as OPD.
