Application progress of liquid biopsy in the diagnosis and treatment of biliary tract cancer
10.3760/cma.j.cn113884-20200902-00469
- VernacularTitle:液态活检技术在胆道肿瘤诊治中的应用进展
- Author:
Mao YANG
1
;
Yongsheng LI
;
Wenguang WU
;
Xuan WANG
;
Fatao LIU
;
Yun LIU
;
Yingbin LIU
Author Information
1. 上海交通大学医学院附属仁济医院胆胰外科 上海市胆道疾病研究重点实验室 癌基因与相关基因国家重点实验室，上海 200127
- Keywords:
Biliary tract neoplasms;
Neoplastic cells, circulating;
Exosomes;
Liquid biopsy
- From:
Chinese Journal of Hepatobiliary Surgery
2021;27(6):472-476
- CountryChina
- Language:Chinese
-
Abstract:
With the development of precision medicine and individualized treatment, tissue biopsy in cancer patients diagnosis and therapy has been broadly used. However, because it’s hard to collect enough samples for biliary tract tumors, liquid biopsy was broadly applied for the diagnosis. In liquid biopsy, circulating tumor cells, circulating tumor DNA, and tumor-derived exosomes carrying tumor-specific information are released from tumor tissue into blood, bile, and other body fluids, which makes tumor biopsy samples easily to be obtained in a non-invasive way. At the same time, through a series of morphological and molecular measurements as well as genetic characterization, liquid biopsy can be used to look for the new early diagnostic markers, and therapeutic targets, monitoring progression and prognosis of diseases. This article outlined the current technology used to detect circulating tumor cells, circulating tumor DNA, and tumor-derived exosomes, and summarizes the latest advances in the clinical application of liquid biopsy in biliary tract cancers.
