Characteristics of immune microenvironment and progress of immune checkpoint inhibitors to cholangiocarcinoma treatment
10.3760/cma.j.cn113884-20200713-00369
- VernacularTitle:胆管癌免疫微环境特点与免疫检查点抑制剂治疗进展
- Author:
Wei LI
1
;
Jinghan WANG
;
Xiaoqing JIANG
Author Information
1. 海军军医大学东方肝胆外科医院胆道一科，上海 200438
- Keywords:
Bile duct neoplasms;
Immunotherapy;
Tumor immune microenvironment;
Immune checkpoint inhibitors
- From:
Chinese Journal of Hepatobiliary Surgery
2021;27(6):466-471
- CountryChina
- Language:Chinese
-
Abstract:
Cholangiocarcinoma is a highly malignant disease with low surgical resection rate. It’s resistant to chemoradiotherapy and the prognosis of cholangiocarcinoma is poor. Although immune checkpoint inhibitors (ICIs) have achieved great success in tumor therapy in recent years, patients with cholangiocarcinoma have a poor response to immunotherapy, because of the complexity and diversity of immune microenvironment. Therefore, understanding the composition and characteristics of the immune microenvironment of cholangiocarcinoma, regulating targets in immune microenvironment, and adopting ICIs combined therapy, is important for immunotherapy for cholangiocarcinoma.
