Correlation analysis between Naples prognostic score and treatment outcomes for locally advanced rectal cancer
10.3760/cma.j.cn113030-20210706-00249
- VernacularTitle:NPS与局部晚期直肠癌新辅助放化疗疗效及预后相关性初步分析
- Author:
Jiahao ZHU
1
;
Qizhong GAO
;
Xinwei GUO
;
Zhengcao LIU
;
Bo YANG
;
Shengjun JI
;
Yutian ZHAO
Author Information
1. 江南大学附属医院肿瘤放疗科，无锡 214000
- Keywords:
Rectal neoplasm, locally advanced/neoadjuvant chemoradiotherapy;
Naples prognostic score;
Prognosis
- From:
Chinese Journal of Radiation Oncology
2021;30(12):1256-1261
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation between the Naples prognostic score (NPS) after preoperative neoadjuvant chemoradiotherapy in locally advanced rectal cancer (LARC) and evaluate the prognostic value of NPS in LARC.Methods:136 patients with LARC meeting the recruitment criteria from 2015 to 2020 were selected. Serum albumin, total cholesterol (TC) were collected and neutrophil-lymphocyte ratio and lymphocyte-monocyte ratio were calculated. All patients were scored and graded according to the NPS rule. The survival rate was calculated with Kaplan- Meier method. Multivariate prognostic analysis was performed by Cox models. Results:There was no significant correlation between NPS score and tumor regression or pathological complete response (pCR) of LARC patients after neoadjuvant therapy ( P=0.192, P=0.163). However, Cox multivariate analysis showed that NPS was an independent risk factor for overall survival (OS) and disease-free survival (DFS) of LARC ( P=0.009, P=0.003), and hierarchical analysis suggested that LARC patients with lower NPS score obtained better prognosis. Besides NPS, tumor size was also an independent risk factor for OS, and tumor size and N stage were the independent risk factors for DFS. Conclusion:NPS has no correlation with tumor regression or pCR for LARC after neoadjuvant chemoradiotherapy, whereas it could serve as an effective predictor for long-term prognosis of LARC.
