Studies of the Timolol Effect on Intraocular Pressure and Concentration in Aqueous Humor in the White Rabbit.
- Author:
Young Don OH
1
;
Hyung Woo KWAK
;
Jae Myung KIM
Author Information
1. Department of Ophthalmology, Nam Seoul Hospital, Korea.
- Publication Type:Original Article
- MeSH:
Aqueous Humor*;
Biopsy, Fine-Needle;
Intraocular Pressure*;
Timolol*
- From:Journal of the Korean Ophthalmological Society
1987;28(3):589-593
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The effect of 0.25% and 0.5% Timolol on intraocular pressure and concentration in aqueous humor was studied after topical instillation in the white rabbit. The intraocular pressure was measured with pneuma tonometer and the Timolol concentration in aqueous humor was measured with High Preformance Liquid Chromatograph after fine needle aspiration of aqueous humor at various time intervals. The results were as follows; 1. The percentage reduction of intraocular pressure increased with time and reached a peak after 3 hours. 2. The concentration of Timolol in aqueous humor increased with time and reached a peak after 3 hours. 3. There was close correlation between intraocular pressure and Timolol concentration in aqueous humor.
