Application of 192Ir brachytherapy in locally recurrent non-small cell lung cancer
10.3760/cma.j.cn113030-20200817-00419
- VernacularTitle:192Ir近距离治疗在局部复发非小细胞肺癌中的应用
- Author:
Hongling LU
1
;
Yunchuan SUN
;
Li XIAO
;
Xinying HE
;
Jianqiang BI
;
Rujing HUANG
;
Tingting HU
;
Xiaoming YIN
;
Wei GUO
;
Hongjuan YANG
;
Wenbo YANG
;
Junjie WANG
Author Information
1. 河北省沧州中西医结合医院放疗科 061000
- Keywords:
Locally recurrent, lung neoplasm/brachytherapy;
Treatment outcome;
Adverse event
- From:
Chinese Journal of Radiation Oncology
2021;30(8):775-779
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical efficacy and adverse events of 192Ir high-dose rate brachytherapy (HDR-BT) in the treatment of locally recurrent non-small cell lung cancer (NSCLC). Methods:Clinical data of 22 cases of recurrent NSCLC after radiotherapy admitted to our hospital from September 2013 to March 2018 were retrospectively analyzed. 192Ir HDR-BT was adopted for reradiotherapy. The prescription dose was 30Gy for 1 fraction. CT scan was reviewed every 1 month in the first 3 months after treatment and every 3 months after 3 months. Local control rate and adverse events were evaluated. The 1-and 2-year overall survival (OS) rates of re-treatment after relapse were calculated. Results:All the 22 patients completed the treatment successfully. The 1-, 3-and 6-month complete response (CR) rates were 9%, 14% and 14%, 82%, 82% and 82% for the partial response (PR) rates, 5%, 0% and 0% for the stable disease (SD) rates, 5%, 5% and 5% for the progressive disease (PD) rates, 91%, 96% and 96% for the objective response rates (ORR), respectively. The 1-and 2-year OS rates of re-treatment after relapse were 59% and 27%. Five patients (23%) experienced acute radiation-induced pneumonitis (3 cases of grade 1 and 2 cases of grade Ⅱ), 4 cases (18%) of radiation-induced bone marrow suppression (3 cases of grade I leukopenia and 1 case of grade I thrombocytopenia) and 1 case of postoperative pneumothorax. All these adverse events were mitigated after symptomatic treatment.Conclusion:192Ir HDR-BT is an efficacious and safe treatment of locally recurrent NSCLC.
