Meta-analysis of the incidence of radiation pneumonitis between European, American and Asian populations
10.3760/cma.j.cn113030-20201114-00554
- VernacularTitle:欧美和亚裔人群放射性肺炎发生率 Meta分析
- Author:
Jia WEI
1
;
Zhen ZHANG
;
Jiaqi YU
;
Huijun JIA
;
Jia TIAN
;
Chunliu MENG
;
Kai REN
;
Lujun ZHAO
Author Information
1. 天津医科大学肿瘤医院放疗科 国家肿瘤临床医学研究中心 天津市 "肿瘤防治" 重点实验室 天津市恶性肿瘤临床医学研究中心 300060
- Keywords:
Lung neoplasm/radiotherapy;
Radiation pneumonitis;
Meta-analysis
- From:
Chinese Journal of Radiation Oncology
2021;30(6):556-562
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the incidence of radiation pneumonitis (RP) between lung cancer patients from the European, American and Asian regions.Methods:The studies related to lung cancer and RP were searched from PubMed, Embase, and Cochrane library. According to the different places where the studies were conducted, the searched studies were divided into two types: Asian studies and European, American and Australian studies. The incidence of RP between two regions was summarized. Studies related to dosimetry parameters were searched from PubMed database.Results:A total of 3, 190 patients from 14studies were included. Meta-analysis results showed that the incidence of ≥ grade 3 RP was similar in patients from Asia and Europe, America and Australia (4.9% vs. 4.6%, P=0.895), whereas the incidence of grade 5 RP in Asia was significantly higher than that in Europe, America and Australia (1.5% vs. 0.2%, P=0.002). Moreover, the lung irradiation dose received by the patients in the Asian group was relatively low. Lung V 20Gy dose limitation standard was reported in 21studies. Further analysis found no statistical significance in lung V 20Gy dose limitation standard between two regions ( P=0.440), and the standard in Asian studies is likely to be even stricter. Conclusions:The incidence of RP after chemoradiotherapy in lung cancer patients in Asia is relatively higher compared with those in Europe, America and Australia. The differences in dose limitation standard should be noted when the thoracic radiation regimen based solely on the data from foreign studies is applied to the patients in Asia.
