Biodosimetry estimation of a case of large area back skin injury caused by accidental irradiation in interventional procedure
10.3760/cma.j.issn.0254-5098.2021.12.002
- VernacularTitle:一起介入治疗意外照射导致背部大面积放射性皮肤损伤患者的生物剂量估算
- Author:
Lin HAN
1
;
Bingjie ZHANG
;
Ping WANG
;
Jie LI
;
Shasha DU
;
Yuxuan MAO
;
Fengling ZHAO
;
Yulong LIU
;
Yumin LYU
Author Information
1. 河南省职业病防治研究院 河南省辐射生物与流行病学医学重点实验室，郑州 450052
- Keywords:
Interventional procedure;
Radiation skin injury;
Unstable chromosomal aberration;
Biological dose estimation;
Dose reconstruction
- From:
Chinese Journal of Radiological Medicine and Protection
2021;41(12):886-891
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate biological dose and retrospective biodosimetry of a case of large area back skin injury caused by suspected interventional procedure.Methods:Peripheral blood from the patient was collected at about 7 months after interventional procedure, and the chromosomal aberrations in peripheral blood cells were analyzed to evaluate the retrospective biodosimetry using the correction factor of dose estimation, Dolphin′s model and Qdr method, respectively. Results:Based on the amounts of semi-automated dic and manually detected dic plus ring, the whole-body average absorbed dose of the victim was estimated to be 0.68-0.95 Gy by four different dose response curves. Over dispersion of dic or dic plus ring was also detected, and the efficiency of dose assessment was obviously increased using dic semi-automatic detection. Based on three different retrospective biodosimetry models, the estimated average absorbed dose was further corrected to be between 1.80-2.86 Gy, which was consistent with clinical diagnosis of degree Ⅳ radiation skin injury.Conclusions:A case of suspected radiation skin injury was confirmed by chromosomal aberration analysis and it’s biodosimetry was reconstructed, suggesting that the unstable chromosomal aberration analysis may be applicable to assess the retrospective biodosimetry of non-uniform local radiation exposure.
