Research progress in miRNAs mediated radiation-induced by stander effect

VernacularTitle:miRNAs介导辐射旁效应研究进展
Author: Yafei SHU ¹ ; Jing GU ; Min HOU ; Yali SHE ; Kai LIU ; Yifan DUAN
Author Information

1. 甘肃中医药大学，兰州　730000
Keywords: miRNAs; Radiation-induced bystander effect; Exosome
From: Chinese Journal of Radiological Medicine and Protection 2021;41(11):862-866
CountryChina
Language:Chinese
Abstract: Radiation-induced bystander effect (RIBE) refers to that irradiated cells release signaling factors and induce responses in nonirradiated cells.In other words, it is the communication between irradiated and nonirradiated cells by intracellular signals. RIBE could influence the efficacy of tumor radiotherapy, but also has potential risk to the normal tissues outside of radiation field. Studies have found that ionizing radiation can induce the alteration of miRNA expression not only in the irradiated cells but also in adjacent nonirradiated tissues, and miRNAs may play an important role in the regulation of signaling pathways between irradiated and nonirradiated bystander cells. This article reviewed the roles of miRNAs in RIBE.