Application of nanoformulations and nanomaterials in the decorporation of radionuclides
10.3760/cma.j.issn.0254-5098.2021.09.013
- VernacularTitle:纳米制剂及纳米材料在放射性核素促排中的应用
- Author:
Xin LI
1
;
Hongxin NING
;
Yazhi ZHAO
;
Yanxin ZHANG
;
Yiliang LI
;
Wenbin HOU
Author Information
1. 天津中医药大学 301617
- Keywords:
Nanometer;
Decorporation;
Radionuclides;
Nuclear radiation
- From:
Chinese Journal of Radiological Medicine and Protection
2021;41(9):711-715
- CountryChina
- Language:Chinese
-
Abstract:
Internal contamination of radionuclides in the event of nuclear emergencies can lead to serious harm to human health. The research and development of radionuclide chelating agents and the application of new technologies can reduce the internal damage caused by radionuclides. Compared with traditional preparations, the nano-preparations have the advantages of improving drug dissolution, targeting and positioning drug release, and easily passing through biofilm barrier. In recent years, many scholars have used different nano-preparation forms for different decorporation drugs, including nanoparticles, nano-liposomes, nano-emulsions, etc., to conduct related research in order to achieve better clinical application effects. Nanomaterials with excellent properties have the advantages of high efficiency, rapid adsorption and high biocompatibility, etc., and have been used more and more widely in radionuclide decorporation. In this paper, combined with the relevant literatures at home and abroad, the internal contamination of radionuclides is classified according to nuclide-deposited sites of tissues and organs, and the applications of related nanoformulations and nanomaterials in radionuclide decorporation are introduced in order to provide reference for further research.
