Experimental research progress of genetically modified mesenchymal stem cells in the treatment of radiation-induced lung injury

VernacularTitle:基因修饰的间充质干细胞在放射性肺损伤治疗中的实验研究进展
Author: Zhijie WAN ¹ ; Songyun ZHAO ; Yanyong YANG ; Fu GAO
Author Information

1. 海军军医大学海军医学系舰船辐射医学防护教研室，上海　200043
Keywords: Mesenchymal stem cells; Genetic modification; Radiation-induced lung injury; Pulmonary fibrosis; Radiation pneumonia
From: Chinese Journal of Radiological Medicine and Protection 2021;41(8):595-601
CountryChina
Language:Chinese
Abstract: Radiation-induced lung injury is a common complication of thoracic malignant tumor radiotherapy and severe nuclear accident injury. Currently, there is no effective treatment on this injury. Mesenchymal stem cells (MSCs) are a group of cells with multi-directional differentiation potential and they can protect lung tissue from radiation damage by homing to the injured site and differentiating to the damaged tissues, secreting cytokines and immune regulation. Further, the genetically modifying mesenchymal stem cells have not only the main characteristics of MSCs, but also can efficiently and stably express or knock down a certain of target genes, thereby enhancing or reducing the sensitivity of mesenchymal stem cells to various physiological stimulus and enhancing its therapeutic effect in radiation-induced lung injury, providing new ideas and new strategies for clinical treatment. This paper reviewed the relevant research progress in recent years.