Role of intestinal stem cells in prevention of radiation-induced intestinal injury

VernacularTitle:肠道干细胞在放射性肠损伤防护中的作用
Author: Ziqi ZHANG ¹ ; Wei LONG ; Wenqing XU
Author Information

1. 中国医学科学院　北京协和医学院放射医学研究所　天津市放射医学与分子核医学重点实验室，天津　300192
Keywords: Radiation-induced intestinal injury; Intestinal stem cells(ISCs); Intestinal radiation protection; Protective agents
From: Chinese Journal of Radiological Medicine and Protection 2021;41(8):579-586
CountryChina
Language:Chinese
Abstract: At present, there is no effective treatment method of radiation-induced intestinal injury. Clinically, only symptomatic remission therapy can be used. Intestinal stem cells (ISCs) have strong renewal ability, which is an important part of intestinal structure regeneration. To promote the recovery of the number and function of ISCs has been a research hotspot in the treatment of radiation gastrointestinal syndrome. This article introduces the important role of ISCs in the protection of radiation-induced intestinal injury and its clinical application significance from the classification and regulatory mechanism of ISCs, and drugs that regulate the damage, apoptosis and repair of stem cells, so as to provide reference for the future research on the role of intestinal stem cells in radiation protection.