Research progress in insufficient fracture after pelvic radiotherapy

VernacularTitle:盆腔放疗后功能不全性骨折的研究进展
Author: Wen LI ¹ ; Jiyuan PAN ; Yi LI ; Hongtao REN ; Yali WANG
Author Information

1. 西安交通大学第二附属医院肿瘤放疗科　710004
Keywords: Pelvic tumor; Radiotherapy; Pelvic insufficiency fracture(PIF)
From: Chinese Journal of Radiological Medicine and Protection 2021;41(6):469-474
CountryChina
Language:Chinese
Abstract: Pelvic radiotherapy is a way for treatment of most pelvic tumors, of which the pelvic insufficiency fracture (PIF) is a long-term complication. In this review, research progress of pelvic insufficiency fracture is summarized and discussed. The pathogenesis of PIF is mainly about inhibition of osteoblasts and the risk factors of PIF include old age, postmenopausal status, absence of hormonal replacement therapy, high number of births, smoking history, low body mass index (BMI), concurrent rheumatoid arthritis, concurrent diabetes mellitus, intracavitary brachytherapy of the high dose rate (HDR-ICBT), high dose of radiotherapy, etc. Effective drugs for prevention or treatment of PIF have not been found yet. Delayed diagnosis and misdiagnosis of PIF can cause serious consequences. As a result, further studies are needed to guide clinical work.