Self-adjustable automatic planning method of intensity modulated radiotherapy based on 3D predicted dose
10.3760/cma.j.issn.0254-5098.2021.06.008
- VernacularTitle:基于三维预测剂量的自调节调强放疗自动计划方法
- Author:
Yongheng YAN
1
;
Maoyun PAN
;
Jieping ZHOU
;
Aidong WU
;
Wenhua WU
;
Xie XU
;
Xi PEI
Author Information
1. 中国科学技术大学核科学技术学院，合肥 230025
- Keywords:
Intensity modulated radiotherapy;
Automatic radiotherapy planning;
Self-adjustable
- From:
Chinese Journal of Radiological Medicine and Protection
2021;41(6):444-449
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To develope a self-adjustable automatic planning method of intensity modulated radiotherapy based on predicted dose, in order to enhance the robustness of automatic planning.Methods:After the patients′ dose by 3D U-Res-Net_B network was predicted, the current dose was calculated based on the last iteration result, then the predicted dose was combined to calculate the target dose and optimized. With all iterations completed or exit conditions satisfied, final treatment plannings would be acquired. A total of 30 cases of rectal cancer were tested to verify the effectiveness of the algorithm.Results:The mean value of planning target volumes′ V100% was (95.03±0.91)% for clinical plans, close to (94.67±1.96)% for automatical plans( P>0.05), and better than (92.90±2.13)% for predicted dose with the statisically significant difference ( t=29.0, P<0.05). Automatic planning′s indexes such as V35 of small intestines, V40 of bladders and V20 - V40 of femoral heads were lower than predicted and clinical ones, with the statisically significant difference( t=4.5-118.0, P<0.05). Discrepancy in other indexes of organs at risk was not statistically significantly different( P>0.05). Conclusions:This method made automatic planning processes more robust and more adaptive to difficult clinical situations.
