Advances in bowel delineation and dose-volume constraint in intensity modulated radiation therapy and 3D conformal radiation therapy for pelvic tumors
10.3760/cma.j.issn.0254-5098.2021.04.014
- VernacularTitle:盆腔肿瘤调强与三维适形放疗肠道勾画与剂量-体积限制的研究进展
- Author:
Bichun XU
1
;
Qi GUO
;
Jianjun QIAN
;
Yingying XU
;
Ye TIAN
Author Information
1. 苏州大学附属第二医院放疗科 215004
- Keywords:
Intensity-modulated radiation therapy;
Adverse events;
Pelvic cavity;
Delineation;
Dose-volume constraint
- From:
Chinese Journal of Radiological Medicine and Protection
2021;41(4):315-320
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal injury is an important toxic response during radiation therapy of pelvic tumors. With the widespread use of precision radiotherapy techniques such as intensity modulated radiation therapy (IMRT), the dose exposed to normal tissues and organs has been significantly reduced. However, the toxic response of the bowel still limits the increase of the dose to the target volume. Therefore, the protection of important organs at risk (OAR), such as the bowel, becomes more and more important while giving adequate irradiated dose to the target volume. Most current studies used loop to contour bowel. For patients who underwent IMRT, the meaningful dose-volume predictors of grade 2 acute intestinal adverse events using bowel loop (small loop + big bowel) delineation included V45 Gy < 50 cm 3,V50 Gy < 13 cm 3, and V55 Gy < 3 cm 3, and the corresponding predicators using bowel bag delineation were V40 Gy < 170 cm 3,V45 Gy < 100 cm 3, and V50 Gy < 33 cm 3.
