Radiation dosimetry and biodistribution of 68Ga-FAPI-04 PET in patients with hepatobiliary tumor
10.3760/cma.j.issn.0254-5098.2021.04.010
- VernacularTitle:肝胆肿瘤患者 68Ga-FAPI-04 PET显像的内照射剂量及分布研究
- Author:
Haiqun XING
1
;
Wenjia ZHU
;
Chengyan DONG
;
Jingnan WANG
;
Ximin SHI
;
Meiqi WU
;
Shaobo YAO
;
Fang LI
;
Li HUO
Author Information
1. 中国医学科学院 北京协和医学院北京协和医院核医学科 核医学分子靶向诊疗北京市重点实验室 100730
- Keywords:
68Ga-FAPI-04;
PET/CT;
Hepatobiliary tumor;
Radiation dosimetry;
Biodistribution
- From:
Chinese Journal of Radiological Medicine and Protection
2021;41(4):293-298
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the radiation dosimetry and biodistribution of 68Ga-FAPI-04 PET/CT in patients with hepatobiliary tumor. Methods:A total of six patients with hepatic lesions who underwent PET/CT examination in Peking Union Medical College Hospital were enrolled. After intravenous injection of radiotracer 68Ga-FAPI-04 at (170.57 ± 14.43) MBq, whole-body imaging were performed at the time points of 3, 10, 15, 20, 30 and 60 min, respectively. Biodistribution pattern was observed. Regions of interest were manually delineated. Radiation dosimetry of all target organs were calculated by Olinda/EXM software. Results:The radioactive uptake dissipated gradually in liver whereas it was relatively stable in tumor lesions. The average SUV max of tumor lesions reached the maximum value (13.87± 2.55) at 20 min after injection. The target-to-background ratio increased with time, reaching the maximum value (10.09 ± 8.17) at 30 min after injection. The average effective dose in total body was (0.020 ± 0.002) mSv/MBq and organ with the highest effective dose was bladder wall at (0.146 ± 0.035) mSv/MBq. Conclusions:The effective dose in total body of 68Ga-FAPI-04 was similar to that of 18F-FDG. 68Ga-FAPI-04 is expected to be a PET/CT radiotracer for hepatobiliary tumors in consideration of rapid tumor uptake, low accumulation of liver background, and no influence of blood sugar levels.
