MiR-103a-3p and miR-107: potential biomarkers for the progression of osteoarthritis
10.3760/cma.j.c141217-20201113-00409
- VernacularTitle:MiR-103a-3p与miR-107：骨关节炎进展过程中的潜在生物标志物
- Author:
Mingyi YANG
1
;
Yani SU
;
Ke XU
;
Kan PENG
;
Aihaiti YIRIXIATI
;
Haishi ZHENG
;
Yanni YANG
;
Yongsong CAI
;
Peng XU
Author Information
1. 延安大学医学院临床医学系 716000
- Keywords:
Osteoarthritis;
Genes;
MicorRNAs;
Biomarkers
- From:
Chinese Journal of Rheumatology
2021;25(9):616-621,C9-2-C9-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the potential Hub genes, key miRNAs, biological processes and related signaling pathways in the pathogenesis of osteoarthritis (OA), and provide bioinformatics basis for the pathogenesis and treatment of OA.Methods:The expression profiling chip of OA synovial tissue sample from Gene Expression Omnibus (GEO) were downloaded, differentially expressed genes (DEGs) were identified, and functional enrichment analysis was performed. A protein-protein interaction network (PPI) was constructed. STRING and Cytoscape was used for module analysis, and the Hub gene was further identified, and further miRNAs mining of the Hub gene was carried out.Results:Finally, 9 Hub genes (SOCS3, BTRC, FBXO32, KLHL22, UBE3A, HUWE1, UBR4, ANAPC5, TRIM50) and 2 key miRNAs (hsa-miR-103a-3P, hsa-miR-107) related to the progression of OA were identified .They might be potential biomarkers for the pathogenesis of OA. We also found that signal transduction, the transcriptional positive regulation of RNA polymerase Ⅱ promoter, and protein serine/threoninase activity had a certain correlation with the pathogenesis of OA. In addition, our analysis results showed that cAMP signaling pathway and Rap1 signaling pathway were also involved in the progression of OA.Conclusion:The potential biological molecules, biological processes and related pathways identified in this study may guide us for the further research on the etiology and treatment of OA.
