Case series of patients with cholesterol crystal embolism syndrome that mimics systemic vasculitis
10.3760/cma.j.c141217-20210409-00132
- VernacularTitle:酷似系统性血管炎的胆固醇结晶栓塞综合征临床分析
- Author:
Zhiming OUYANG
1
;
Wencheng ZENG
;
Jinjian LIANG
;
Qianhua LI
;
Donghui ZHENG
;
Xiuning WEI
;
Lie DAI
;
Yingqian MO
Author Information
1. 中山大学孙逸仙纪念医院风湿免疫科，广州 510120
- Keywords:
Atherosclerosis;
Systemic vasculitis;
Cholesterol crystal embolism syndrome
- From:
Chinese Journal of Rheumatology
2021;25(9):597-604,C9-1
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To improve the awareness of cholesterol crystal embolism syndrome (CCE) inrheumatologists.Methods:The clinical characteristics of 40 Chinese CCE patients admitted to our department (one case) were summarize and in the literature (thirty-nine cases) were reviewed.Results:Among these 40 patients, 87.5%(35/40) were male and the mean age was (68±6) years. All patients suffered from athero-sclerosis and 87.5%(35/40) of them had precipitating factors such as endovascular intervention, vascular surgery, anticoagulant, or thrombolytic therapy. The clinical manifestations included renal insufficiency (90.0%, 36/40), blue toe syndrome (82.5%, 33/40), ulceration or gangrene (25.0%, 10/40), and livedo reticularis (15%, 6/40). Acute phase reactant was tested in 25 cases, of whom 84.0%(21/25) showed elevated C-reactive protein (CRP) and 56.0%(14/25) showed elevated erythrocyte sedimentation rate (ESR).Conclusion:Rheumatologists should be alert that CCE is one of the differential diagnosis of systemic vasculitis, especially for patients with severe atherosclerosis.
