Bone pain, thyroid nodule and lymphadenectasis: a report of one case with literature review
10.3760/cma.j.cn141217-20210114-00011
- VernacularTitle:临床病例评析——骨痛 甲状腺结节 淋巴结肿大
- Author:
Bo ZANG
1
;
Hui HUA
;
Feng HOU
;
Xianqi FENG
;
Dapeng HAO
;
Zhenguang WANG
;
Xu ZHANG
;
Bin LIU
Author Information
1. 青岛大学附属医院风湿免疫科 266071
- Keywords:
Thyroid nodule;
Lymphadenectasis;
Mastocytosis, systemic;
Diagnosis
- From:
Chinese Journal of Rheumatology
2021;25(8):516-520,C8-1
- CountryChina
- Language:Chinese
-
Abstract:
Objective:By analyzing the clinical and pathologic manifestations of systemic mastocytosis (SM) to improve the recognition of the disease.Methods:Clinical manifestations, diagnosis and treatment of a middle-aged male patient with SM was reported with multidisciplinary discussions.Results:A middle-aged man with bone pain, thyroid nodules and lymphadenectasis came to our clinic. Thyroid cancer with lymph node and bone metastasis was suspected by imaging examination. The pathological results showed cell proliferation with transparent cytoplasm and irregular nuclear in the trabecular bone. Toluidine blue staining showed the proliferated cells were mast cells(+). Immunohistochemistry showed proliferating mast cells stained with CD117 and CD2. SM with extensive bone marrow involvement was diagnosed and treated with thalidomide and calcitriol.Conclusion:Knowing the characteristics of SM is helpful for accurate diagnosis and treatment.
